Human beings are part of an ecosystem of organisms whose main impulse is to survive. Survival to what? To entropy, violence, cold, the void.
We are surrounded by an infinity of possibilities that can lead us to failure of survival. There are obstacles surrounding us in every direction. This is true for all the species inhabiting our planet.
Humanity is the most successful species on this planet. Part of the reason why is because our ancestors did not shy away from difficulties. Rather those obstacles were faced and overcome with much pain and sacrifice.
"In man's life his time is a mere instant, his existence a flux, his perception fogged, his whole bodily composition rotting, his mind a whirligig, his fortune unpredictable, his fame unclear. To put it shortly: all things of the body stream away like a river, all things of the mind are dreams and delusion; life is warfare, and a visit in a strange land; the only lasting fame is oblivion.Marcus Aurelius - Meditations, book two, 17
What then can escort us on our way? One thing, and one thing only: philosophy. This consists in keeping the divinity within us inviolate and free from harm, master of pleasure and pain, doing nothing without aim, truth, or integrity, and independent of others' action or failure to act. Further, accepting all that happens and is allotted to it as coming from that other source which is its own origin: and at all times awaiting death with the glad confidence that it is nothing more than the dissolution of the elements of which every living creature is composed. Now if there is nothing fearful for the elements themselves in their constant changing of each into another, why should one look anxiously in prospect at the change and dissolution of them all? This is in accordance with nature: and nothing harmful is in accordance with nature."
The opposites are stagnation, the absence of flow, or isolation, the absence of connection, even rejection. The Life within us urges to connect to the Life without us.